Common Medications May Affect Immune Response to COVID-19

Drugs such as aspirin, ibuprofen, and acetaminophen can be used with or against the immune system.

A new study by researchers from the Department of Medicine and Health, University of Sydney, suggests that antibiotics and heat treatment have negative or positive effects on the drug-dependent prevention of infectious diseases such as COVID-19. †

March 1, The results, published in the British Journal of Clinical Pharmacology, are based on a comprehensive clinical trial examining the effects of acetaminophen (acetaminophen), a non-steroidal anti-inflammatory drug (NSAID) such as aspirin and ibuprofen, and opioids . † and analgesics morphine, codeine in the immune system.

“Our research shows that some antibiotics and antimicrobials work against the immune system, others increase the risk of infection or exposure. The impact on the disease is not good,” said Christina Abdel-Shaheed, MD of Therapeutic Sciences in Sydney. †

An extensive study by the research team found that aspirin is the cheapest and most effective treatment for tuberculosis, an infectious disease that affects the lungs. As other studies have shown, antidepressants can also affect COVID-19. BMJ Heart 2021 A report published in the October issue found that aspirin improves cardiovascular benefits, and studies published the same year in the journal Clinical Epidemiology and Global Health found that aspirin use was lower. Mortality in patients with COVID-19.

If you take antipyretics alone, these drugs (such as acetaminophen, ibuprofen, and aspirin) can reduce the use of the immune system during vaccination.

dr. Abdel-Shaheed said, “Using acetaminophen or ibuprofen before vaccination, such as COVID-19, is not recommended to protect against the flu or migraines, as it may reduce the need for antibiotic resistance,” said Dr. Abdel Shaheed. Abdel Shaheed. † Ibuprofen is not recommended for the treatment of measles due to the increased risk of secondary skin infections.

The authors also found that an indomethacin stimulant (used to reduce symptoms of mild to moderate arthritis or gout) may reduce the activity of COVID-19 infections, but this should be a serious test in humans.

Justin Beardsley, MBChB, PhD, a specialist at Westmead Hospital and a researcher at the Sydney Institute for Disease Control, describes one of the key findings that morphine, used as a pain reliever, can shut down immune cells. † system and increases the risk of infection, especially after treatment for leukemia.
Further research is needed in this area of ​​research to understand how traditional medicine can be used to treat infectious diseases, says Andrew McLaughlin, MD, director of the Sydney School of Medicine and member of the research team. He said: “Due to the urgent need for new treatments for COVID-19 due to immunosuppression and reduced antibiotic efficacy, we now need more drugs than ever before to stabilize or improve the effectiveness of antibiotics,” he said.

Julie Parsonnet, an outpatient professor at Stanford University in California who did not participate in the study, says many of these studies are incompatible with the effects of these drugs on our bodies. Prevention cannot be ruled out. in infectious diseases. For example, some studies suggest that aspirin and indomethacin may help prevent COVID-19-related deaths, while other studies suggest there are no side effects.

“It’s hard to know the truth without testing,” says Dr. parsonnet. “Research shows that we need to do more public research on this topic.